Our laboratory broadly investigates molecular, cellular and in vivo pathways of inflammation and innate immune responses to infection. At the gene and molecular level, our work focuses on the multiple functions of serpins, a large family of inhibitors of serine and cysteine proteases. At the cellular level, our expertise lies with the biology of innate immune cells and particularly neutrophils. At the level of the organism, we are interested in lung diseases and particularly the role of cigarette smoke exposure and genetic defects on disease development and progression including chronic obstructive pulmonary disease, bacterial infections, multiple sclerosis and cancer. Our translational research uses innovative unbiased approaches and targeted transgenic models to investigate pathways amenable to therapeutic intervention in infectious, inflammatory and proliferative diseases.