2024
Fernandez-Rojo, Manuel A; Pearen, Michael A; Burgess, Anita G; Ikonomopoulou, Maria P; Hoang-Le, Diem; Genz, Berit; Saggiomo, Silvia L; Nawaratna, Sujeevi S K; Poli, Maura; Reissmann, Regina; Gobert, Geoffrey N; Deutsch, Urban; Engelhardt, Britta; Brooks, Andrew J; Jones, Alun; Arosio, Paolo; Ramm, Grant A
(2024).
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation.
Science signaling, 17(830)
American Association for the Advancement of Science
10.1126/scisignal.ade4335
Berve, Kristina; Michel, Julia; Tietz, Silvia; Blatti, Claudia; Ivan, Daniela; Enzmann, Gaby; Lyck, Ruth; Deutsch, Urban; Locatelli, Giuseppe; Engelhardt, Britta
(2024).
Junctional adhesion molecule-A deficient mice are protected from severe experimental autoimmune encephalomyelitis. (In Press).
European journal of immunology(e2350761), e2350761.
Wiley-VCH
10.1002/eji.202350761
2023
Saltarin, Federico; Wegmüller, Adrian; Bejarano, Leire; Ildiz, Eco Su; Zwicky, Pascale; Vianin, Andréj; Spadin, Florentin; Soukup, Klara; Wischnewski, Vladimir; Engelhardt, Britta; Deutsch, Urban; Marques, Ines J.; Frenz, Martin; Joyce, Johanna A.; Lyck, Ruth
(2023).
Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation.
Cancers, 15(20), p. 5071.
MDPI AG
10.3390/cancers15205071
Mapunda, Josephine A; Pareja, Javier; Vladymyrov, Mykhailo; Bouillet, Elisa; Hélie, Pauline; Pleskač, Petr; Barcos, Sara; Andrae, Johanna; Vestweber, Dietmar; McDonald, Donald M; Betsholtz, Christer; Deutsch, Urban; Proulx, Steven T; Engelhardt, Britta
(2023).
VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation.
Nature communications, 14(1), p. 5837.
Nature Publishing Group
10.1038/s41467-023-41580-4
Aydin, Sidar; Pareja, Javier; Schallenberg, Vivianne M; Klopstein, Armelle; Gruber, Thomas; Page, Nicolas; Bouillet, Elisa; Blanchard, Nicolas; Liblau, Roland; Körbelin, Jakob; Schwaninger, Markus; Johnson, Aaron J; Schenk, Mirjam; Deutsch, Urban; Merkler, Doron; Engelhardt, Britta
(2023).
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown.
Nature communications, 14(1), p. 3106.
Nature Publishing Group
10.1038/s41467-023-38703-2
2022
Marchetti, Luca; Francisco, David; Soldati, Sasha; Haghayegh Jahromi, Neda; Barcos, Sara; Gruber, Isabelle; Pareja R., Javier; Thiriot, Aude; von Andrian, Ulrich; Deutsch, Urban; Lyck, Ruth; Bruggmann, Rémy; Engelhardt, Britta
(2022).
ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.
European journal of immunology, 52(1), pp. 161-177.
Wiley
10.1002/eji.202149238
2021
Baier, Felix Alexander; Sánchez-Taltavull, Daniel; Yarahmadov, Tural; Castellà, Cristina Gómez; Jebbawi, Fadi; Keogh, Adrian; Tombolini, Riccardo; Odriozola, Adolfo; Castro Dias, Mariana; Deutsch, Urban; Furuse, Mikio; Engelhardt, Britta; Zuber, Benoît; Odermatt, Alex; Candinas, Daniel; Keogh-Stroka, Deborah M.
(2021).
Loss of claudin-3 impairs hepatic metabolism, biliary barrier function and cell proliferation in the murine liver.
Cellular and molecular gastroenterology and hepatology, 12(2), pp. 745-767.
Elsevier
10.1016/j.jcmgh.2021.04.003
Castro Dias, Mariana; Odriozola Quesada, Adolfo; Soldati, Sasha; Bösch, Fabio; Gruber, Isabelle; Hildbrand, Tobias; Sönmez, Derya; Khire, Tejas; Witz, Guillaume; McGrath, James L.; Piontek, Jörg; Kondoh, Masuo; Deutsch, Urban; Zuber, Benoît; Engelhardt, Britta
(2021).
Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood–brain barrier.
Journal of cell science, 134(8)
Company of Biologists Limited
10.1242/jcs.253880
Sasson, Esther; Anzi, Shira; Bell, Batia; Yakovian, Oren; Zorsky, Meshi; Deutsch, Urban; Engelhardt, Britta; Sherman, Eilon; Vatine, Gad; Dzikowski, Ron; Ben-Zvi, Ayal
(2021).
Nano-scale architecture of blood-brain barrier tight-junctions.
eLife, 10
eLife Sciences Publications
10.7554/eLife.63253
2020
Bruggisser, Julia; Tarek, Basma; Wyder, Marianne; Müller, Philipp; von Ballmoos, Christoph; Witz, Guillaume; Enzmann, Gaby; Deutsch, Urban; Engelhardt, Britta; Posthaus, Horst
(2020).
CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin.
Cell host & microbe, 28(1), pp. 69-78.
Cell Press
10.1016/j.chom.2020.05.003
Li, Zhilin; Korhonen, Emilia A; Merlini, Arianna; Strauss, Judith; Wihuri, Eleonoora; Nurmi, Harri; Antila, Salli; Paech, Jennifer; Deutsch, Urban; Engelhardt, Britta; Chintharlapalli, Sudhakar; Koh, Gou Young; Flügel, Alexander; Alitalo, Kari
(2020).
Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS.
The journal of clinical investigation, 130(4), pp. 1977-1990.
American Society for Clinical Investigation
10.1172/JCI130308
Haghayegh Jahromi, Neda; Marchetti, Luca; Moalli, Federica; Duc, Donovan; Basso, Camilla; Tardent, Heidi; Kaba, Elisa; Deutsch, Urban; Pot, Caroline; Sallusto, Federica; Stein, Jens V.; Engelhardt, Britta
(2020).
Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology, 10(3056), p. 3056.
Frontiers Research Foundation
10.3389/fimmu.2019.03056
2019
Garnier, Arnaud; Laffont, Sophie; Garnier, Laure; Kaba, Elisa; Deutsch, Urban; Engelhardt, Britta; Guéry, Jean-Charles
(2019).
CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation.
European journal of immunology, 49(11), pp. 2030-2043.
Wiley-VCH
10.1002/eji.201948086
Castro Dias, Mariana; Coisne, Caroline; Baden, Pascale; Enzmann, Gaby; Garrett, Lillian; Becker, Lore; Hölter, Sabine M; Hrabě de Angelis, Martin; Deutsch, Urban; Engelhardt, Britta
(2019).
Claudin-12 is not required for blood-brain barrier tight junction function.
Fluids and barriers of the CNS, 16(1), p. 30.
BioMed Central
10.1186/s12987-019-0150-9
Castro Dias, Mariana; Coisne, Caroline; Lazarevic, Ivana; Baden, Pascale; Hata, Masaki; Iwamoto, Noriko; Ferreira Francisco, David Miguel; Vanlandewijck, Michael; He, Liqun; Baier, Felix A.; Stroka, Deborah; Bruggmann, Rémy; Lyck, Ruth; Enzmann, Gaby; Deutsch, Urban; Betsholtz, Christer; Furuse, Mikio; Tsukita, Shoichiro; Engelhardt, Britta
(2019).
Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers.
Scientific reports, 9(1), p. 10702.
Springer Nature
10.1038/s41598-019-43511-0
Enzmann, Gaby; Adelfio, Roberto; Godel, Aurélie; Haghayegh Jahromi, Neda; Tietz, Silvia; Burgener, Sabrina S.; Deutsch, Urban; Wekerle, Hartmut; Benarafa, Charaf; Engelhardt, Britta
(2019).
The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis.
International journal of molecular sciences, 20(6)
Molecular Diversity Preservation International MDPI
10.3390/ijms20061433
Mota Castro Dias, Mariana; Coisne, Caroline Marie; Lazarevic, Ivana; Baden, Pascale; Hata, Masaki; Iwamoto, Noriko; Francisco, David Miguel Ferreira; Vanlandewijck, Michael; He, Liqun; Baier, Felix Alexander; Keogh-Stroka, Deborah M.; Bruggmann, Rémy; Lyck, Ruth; Enzmann, Gaby; Deutsch, Urban; Betsholtz, Christer; Furuse, Mikio; Tsukita, Shoichiro; Engelhardt, Britta
(2019).
Claudin-3-deficient C57BL/6J mice display intact brain barriers.
Scientific Reports, 9(1), p. 203.
Nature Publishing Group
10.1038/s41598-018-36731-3
Wimmer, Isabella; Tietz, Silvia; Nishihara, Hideaki; Deutsch, Urban; Sallusto, Federica; Gosselet, Fabien; Lyck, Ruth; Muller, William A; Lassmann, Hans; Engelhardt, Britta
(2019).
PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation.
Frontiers in immunology, 10, p. 711.
Frontiers Research Foundation
10.3389/fimmu.2019.00711
2018
Tietz, Silvia; Périnat, Therese; Greene, Gretchen Thompson; Enzmann, Gaby; Deutsch, Urban; Adams, Ralf; Imhof, Beat; Aurrand-Lions, Michel; Engelhardt, Britta
(2018).
Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis.
Brain, behavior, and immunity, 73, pp. 3-20.
Elsevier
10.1016/j.bbi.2018.06.014
2017
Lyck, Ruth; Lécuyer, Marc-André; Abadier, Michael Magdy Labib; Wyss, Christof B.; Matti, Christoph; Rosito, Maria; Enzmann, Gaby; Zeis, Thomas; Michel, Laure; García Martín, Ana B; Sallusto, Federica; Gosselet, Fabien; Deutsch, Urban; Weiner, Joshua A.; Schaeren-Wiemers, Nicole; Prat, Alexandres; Engelhardt, Britta
(2017).
ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier.
Journal of cerebral blood flow and metabolism, 37(8), pp. 2894-2909.
Nature Publishing Group
10.1177/0271678X16678639
Haghayegh Jahromi, Neda; Tardent, Heidi; Enzmann, Gaby; Deutsch, Urban; Kawakami, Naoto; Bittner, Stefan; Vestweber, Dietmar; Zipp, Frauke; Stein, Jens Volker; Engelhardt, Britta
(2017).
A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology, 8, p. 406.
10.3389/fimmu.2017.00406
2016
Fan, Zhichao; McArdle, Sara; Marki, Alex; Mikulski, Zbigniew; Gutierrez, Edgar; Engelhardt, Britta; Deutsch, Urban; Ginsberg, Mark; Groisman, Alex; Ley, Klaus
(2016).
Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.
Nature communications, 7, p. 12658.
Nature Publishing Group
10.1038/ncomms12658
2015
Broggini, Thomas; Czabanka, Marcus; Piffko, Andras; Harms, Christoph; Hoffmann, Christian; Mrowka, Ralf; Wenke, Frank; Deutsch, Urban; Grötzinger, Carsten; Vajkoczy, Peter
(2015).
ICAM1 depletion reduces spinal metastasis formation in vivo and improves neurological outcome.
European spine journal, 24(10), pp. 2173-2181.
Springer
10.1007/s00586-015-3811-7
Abadier, Michael Magdy Labib; Haghayegh Jahromi, Neda; Cardoso Alves, Ludmila; Boscacci, Rémy; Vestweber, Dietmar; Barnum, Scott; Deutsch, Urban; Engelhardt, Britta; Lyck, Ruth
(2015).
Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier.
European journal of immunology, 45(4), pp. 1043-1058.
Wiley-VCH
10.1002/eji.201445125
2014
Liu, Ju; Deutsch, Urban; Fung, Iris; Lobe, Corrinne G
(2014).
Conditional and inducible transgene expression in endothelial and hematopoietic cells using Cre/loxP and tetracycline-off systems.
Experimental and therapeutic medicine, 8(5), pp. 1351-1356.
Spandidos Publ.
10.3892/etm.2014.1965
Liu, Ju; Dong, Fengyun; Fung, Iris; Chen, Edwin; Allen, Thaddeus D; Deutsch, Urban; Lobe, Corrinne G
(2014).
Postnatal Notch1 activation induces T‑cell malignancy in conditional and inducible mouse models.
International journal of oncology, 45(5), pp. 1997-2004.
Spandidos Publications
10.3892/ijo.2014.2626
Liu, Ju; Deutsch, Urban; Jeong, James; Lobe, Corrinne G
(2014).
Constitutive notch signaling in adult transgenic mice inhibits bFGF-induced angiogenesis and blocks ovarian follicle development.
Genesis, 52(9), pp. 809-816.
Wiley-Liss
10.1002/dvg.22790
Sathiyanadan, Karthik; Coisne, Caroline Marie; Enzmann, Gaby; Deutsch, Urban; Engelhardt, Britta
(2014).
PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE.
European journal of immunology, 44(8), pp. 2287-2294.
Wiley-VCH
10.1002/eji.201344214
Minten, Carsten; Alt, Carsten; Gentner, Melanie; Frei, Elisabeth; Deutsch, Urban; Lyck, Ruth; Schaeren-Wiemers, Nicole; Rot, Antal; Engelhardt, Britta
(2014).
DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation.
Brain, 137(Pt 5), pp. 1454-1469.
Oxford University Press
10.1093/brain/awu045
2013
Ziegler, Tilman; Horstkotte, Jan; Schwab, Claudia; Pfetsch, Vanessa; Weinmann, Karolina; Dietzel, Steffen; Rohwedder, Ina; Hinkel, Rabea; Gross, Lisa; Lee, Seungmin; Hu, Junhao; Soehnlein, Oliver; Franz, Wolfgang M.; Sperandio, Markus; Pohl, Ulrich; Thomas, Markus; Weber, Christian; Augustin, Hellmut G.; Fässler, Reinhard; Deutsch, Urban; ...
(2013).
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis.
Journal of clinical investigation, 123(8), pp. 3436-3445.
American Society for Clinical Investigation
10.1172/JCI66549
2012
Wyss, Lena; Schäfer, Julia; Liebner, Stefan; Mittelbronn, Michel; Deutsch, Urban; Enzmann, Gaby; Adams, Ralf H.; Aurrand-Lions, Michel; Plate, Karl H.; Imhof, Beat A.; Engelhardt, Britta
(2012).
Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus.
PLoS ONE, 7(9), e45619.
Lawrence, Kans.: Public Library of Science
10.1371/journal.pone.0045619
2011
Bill, Ruben; Döring, Axinia; Deutsch, Urban; Engelhardt, Britta
(2011).
PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice.
Journal of neuroimmunology, 232(1-2), pp. 207-8.
Amsterdam: Elsevier
10.1016/j.jneuroim.2010.10.008
Pfeiffer, Friederike; Schäfer, Julia; Lyck, Ruth; Makrides, Victoria; Brunner, Sarah; Schaeren-Wiemers, Nicole; Deutsch, Urban; Engelhardt, Britta
(2011).
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.
Acta neuropathologica, 122(5), pp. 601-14.
Berlin: Springer-Verlag
10.1007/s00401-011-0883-2
Döring, Axinia; Pfeiffer, Friederike; Meier, Matthias; Dehouck, Bénédicte; Tauber, Silke; Deutsch, Urban; Engelhardt, Britta
(2011).
TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis.
European journal of immunology, 41(3), pp. 813-21.
Weinheim: Wiley-VCH
10.1002/eji.201040912
2010
Chadjichristos, C E; Scheckenbach, K E L; van Veen, T A B; Richani Sarieddine, M Z; de Wit, C; Yang, Z; Roth, I; Bacchetta, M; Viswambharan, H; Foglia, B; Dudez, T; van Kempen, M J A; Coenjaerts, F E J; Miquerol, L; Deutsch, U; Jongsma, H J; Chanson, M; Kwak, B R
(2010).
Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion.
Circulation, 121(1), pp. 123-31.
Baltimore, Md.: Lippincott Williams & Wilkins
10.1161/CIRCULATIONAHA.109.867176
Pfister, Frederick; Wang, Yumei; Schreiter, Kay; vom Hagen, Franziska; Altvater, Karin; Hoffmann, Sigrid; Deutsch, Urban; Hammes, Hans-Peter; Feng, Yuxi
(2010).
Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia.
Acta diabetologica, 47(1), pp. 59-64.
Milano: Springer
10.1007/s00592-009-0099-2
Boscacci, Rémy T; Pfeiffer, Friederike; Gollmer, Kathrin; Checa Sevilla, Ana Isabel; Martin, Ana Maria; Soriano, Silvia Fernandez; Natale, Daniela; Henrickson, Sarah; von Andrian, Ulrich H; Fukui, Yoshinori; Mellado, Mario; Deutsch, Urban; Engelhardt, Britta; Stein, Jens V
(2010).
Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing.
Blood, 116(6), pp. 915-25.
Washington, D.C.: American Society of Hematology
10.1182/blood-2009-11-254334
Steiner, Oliver; Coisne, Caroline; Cecchelli, Roméo; Boscacci, Rémy; Deutsch, Urban; Engelhardt, Britta; Lyck, Ruth
(2010).
Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium.
Journal of immunology, 185(8), pp. 4846-55.
Bethesda, Md.: American Association of Immunologists
10.4049/jimmunol.0903732
Wang, Yingdi; Nakayama, Masanori; Pitulescu, Mara E; Schmidt, Tim S; Bochenek, Magdalena L; Sakakibara, Akira; Adams, Susanne; Davy, Alice; Deutsch, Urban; Lüthi, Urs; Barberis, Alcide; Benjamin, Laura E; Mäkinen, Taija; Nobes, Catherine D; Adams, Ralf H
(2010).
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.
Nature, 465(7297), pp. 483-6.
London: Macmillan Journals Ltd.
10.1038/nature09002
2009
Feng, Yuxi; Vom Hagen, Franziska; Wang, Yumei; Beck, Susanne; Schreiter, Kay; Pfister, Frederick; Hoffmann, Sigrid; Wagner, Patrick; Seeliger, Mathias; Molema, Grietje; Deutsch, Urban; Hammes, Hans-Peter
(2009).
The absence of angiopoietin-2 leads to abnormal vascular maturation and persistent proliferative retinopathy.
Thrombosis and haemostasis, 102(1), pp. 120-30.
Stuttgart: Schattauer
10.1160/TH08-09-0567
Feng, Yuxi; Wang, Yumei; Pfister, Frederick; Hillebrands, Jan-Luuk; Deutsch, Urban; Hammes, Hans-Peter
(2009).
Decreased hypoxia-induced neovascularization in angiopoietin-2 heterozygous knockout mouse through reduced MMP activity.
Cellular physiology and biochemistry, 23(4-6), pp. 277-84.
Basel: Karger
10.1159/000218174
Winderlich, Mark; Keller, Linda; Cagna, Giuseppe; Broermann, Andre; Kamenyeva, Olena; Kiefer, Friedemann; Deutsch, Urban; Nottebaum, Astrid F; Vestweber, Dietmar
(2009).
VE-PTP controls blood vessel development by balancing Tie-2 activity.
Journal of cell biology, 185(4), pp. 657-71.
New York, N.Y.: Rockefeller Institute Press
10.1083/jcb.200811159
Noell, Susan; Fallier-Becker, Petra; Deutsch, Urban; Mack, Andreas F; Wolburg, Hartwig
(2009).
Agrin defines polarized distribution of orthogonal arrays of particles in astrocytes.
Cell and tissue research, 337(2), pp. 185-95.
Heidelberg: Springer
10.1007/s00441-009-0812-z
Kokai, Enikö; Voss, Florian; Fleischer, Frank; Kempe, Sybille; Marinkovic, Dragan; Wolburg, Hartwig; Leithäuser, Frank; Schmidt, Volker; Deutsch, Urban; Wirth, Thomas
(2009).
Myc regulates embryonic vascular permeability and remodeling.
Circulation research, 104(10), pp. 1151-9.
Baltimore, Md.: Lippincott Williams & Wilkins
10.1161/CIRCRESAHA.108.191460
Reiss, Yvonne; Knedla, Anette; Tal, Andrea O; Schmidt, Mirko H H; Jugold, Manfred; Kiessling, Fabian; Burger, Angelika M; Wolburg, Hartwig; Deutsch, Urban; Plate, Karl H
(2009).
Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2.
Journal of pathology, 217(4), pp. 571-80.
Chichester: Wiley
10.1002/path.2484
2008
Dufourcq, Pascale; Leroux, Lionel; Ezan, Jérome; Descamps, Betty; Lamazière, Jean-Marie Daniel; Costet, Pierre; Basoni, Caroline; Moreau, Catherine; Deutsch, Urban; Couffinhal, Thierry; Duplàa, Cécile
(2008).
Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation.
American journal of pathology, 172(1), pp. 37-49.
New York, N.Y.: Elsevier
10.2353/ajpath.2008.070130
Deutsch, Urban; Schlaeger, Thorsten M; Dehouck, Bénédicte; Döring, Axinia; Tauber, Silke; Risau, Werner; Engelhardt, Britta
(2008).
Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice.
Experimental cell research, 314(6), pp. 1202-16.
San Diego, Calif.: Elsevier
10.1016/j.yexcr.2007.12.026
Feng, Yuxi; Pfister, Frederick; Schreiter, Kay; Wang, Yumei; Stock, Oliver; Vom Hagen, Franziska; Wolburg, Hartwig; Hoffmann, Sigrid; Deutsch, Urban; Hammes, Hans-Peter
(2008).
Angiopoietin-2 deficiency decelerates age-dependent vascular changes in the mouse retina.
Cellular physiology and biochemistry, 21(1-3), pp. 129-36.
Basel: Karger
10.1159/000113755
Swendeman, Steven; Mendelson, Karen; Weskamp, Gisela; Horiuchi, Keisuke; Deutsch, Urban; Scherle, Peggy; Hooper, Andrea; Rafii, Shahin; Blobel, Carl P
(2008).
VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling.
Circulation research, 103(9), pp. 916-8.
Baltimore, Md.: Lippincott Williams & Wilkins
10.1161/CIRCRESAHA.108.184416
Leen, Laetitia Lam Shang; Filipe, Cédric; Billon, Audrey; Garmy-Susini, Barbara; Jalvy, Sandra; Robbesyn, Fanny; Daret, Danièle; Allières, Cécile; Rittling, Susan R; Werner, Nikos; Nickenig, Georg; Deutsch, Urban; Duplàa, Cécile; Dufourcq, Pascale; Lenfant, Françoise; Desgranges, Claude; Arnal, Jean-François; Gadeau, Alain-Pierre
(2008).
Estrogen-stimulated endothelial repair requires osteopontin.
Arteriosclerosis, thrombosis, and vascular biology, 28(12), pp. 2131-6.
Philadelphia, Pa.: Lippincott Williams & Wilkins
10.1161/ATVBAHA.108.167965
Pfister, Frederick; Feng, Yuxi; vom Hagen, Franziska; Hoffmann, Sigrid; Molema, Grietje; Hillebrands, Jan-Luuk; Shani, Moshe; Deutsch, Urban; Hammes, Hans-Peter
(2008).
Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy.
Diabetes, 57(9), pp. 2495-502.
Alexandria, Va.: American Diabetes Association
10.2337/db08-0325
Saharinen, Pipsa; Eklund, Lauri; Miettinen, Juho; Wirkkala, Riikka; Anisimov, Andrey; Winderlich, Mark; Nottebaum, Astrid; Vestweber, Dietmar; Deutsch, Urban; Koh, Gou Young; Olsen, Bjorn R; Alitalo, Kari
(2008).
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts.
Nature cell biology, 10(5), pp. 527-37.
London: Nature Publishing Group
10.1038/ncb1715
2007
Döring, Axinia; Wild, Martin; Vestweber, Dietmar; Deutsch, Urban; Engelhardt, Britta
(2007).
E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice.
Journal of immunology, 179(12), pp. 8470-9.
Bethesda, Md.: American Association of Immunologists
Yuan, Hai Tao; Venkatesha, Shivalingappa; Chan, Barden; Deutsch, Urban; Mammoto, Tadanori; Sukhatme, Vikas P; Woolf, Adrian S; Karumanchi, S Ananth
(2007).
Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival.
FASEB journal, 21(12), pp. 3171-83.
Bethesda, Md.: Federation of American Societies for Experimental Biology
10.1096/fj.07-8487com
Feng, Yuxi; vom Hagen, Franziska; Pfister, Frederick; Djokic, Snezana; Hoffmann, Sigrid; Back, Walter; Wagner, Patrick; Lin, Jihong; Deutsch, Urban; Hammes, Hans-Peter
(2007).
Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression.
Thrombosis and haemostasis, 97(1), pp. 99-108.
Stuttgart: Schattauer
10.1160/TH06-05-0277
2006
Bäumer, Sebastian; Keller, Linda; Holtmann, Astrid; Funke, Ruth; August, Benjamin; Gamp, Alexander; Wolburg, Hartwig; Wolburg-Buchholz, Karen; Deutsch, Urban; Vestweber, Dietmar
(2006).
Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development.
Blood, 107(12), pp. 4754-62.
Washington, D.C.: American Society of Hematology
10.1182/blood-2006-01-0141
2005
vom Hagen, F; Feng, Y; Hillenbrand, A; Hoffmann, S; Shani, M; Deutsch, U; Hammes, HP
(2005).
Early loss of arteriolar smooth muscle cells: more than just a pericyte loss in diabetic retinopathy.
Experimental and clinical endocrinology & diabetes, 113(10), pp. 573-6.
Stuttgart: Thieme
10.1055/s-2005-872894
Hoffmann, J; Feng, Y; vom Hagen, F; Hillenbrand, A; Lin, J; Erber, R; Vajkoczy, P; Gourzoulidou, E; Waldmann, H; Giannis, A; Wolburg, H; Shani, M; Jaeger, V; Weich, HA; Preissner, KT; Hoffmann, S; Deutsch, U; Hammes, HP
(2005).
Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity.
FASEB journal, 14(19), pp. 2035-6.
Bethesda, Md.: Federation of American Societies for Experimental Biology
10.1096/fj.04-2109fje
May, T; Mueller, PP; Weich, H; Froese, N; Deutsch, U; Wirth, D; Kröger, A; Hauser, H
(2005).
Establishment of murine cell lines by constitutive and conditional immortalization.
Journal of biotechnology, 120(1), pp. 99-110.
Amsterdam: Elsevier
10.1016/j.jbiotec.2005.03.027
2004
Ivkovic, S; Deutsch, U; Silberbach, A; Walraph, E; Mannel, M
(2004).
Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: effects on the immune system.
Advances in therapy, 21(2), pp. 135-147.
Springer
10.1007/BF02850340
Deutsch, U
(2004).
Semaphorins guide PerPlexeD endothelial cells.
Developmental cell, 7(1), pp. 1-2.
Cambridge, Mass.: Cell Press
10.1016/j.devcel.2004.06.012
Hammes, HP; Lin, J; Wagner, P; Feng, Y; Vom Hagen, F; Krzizok, T; Renner, O; Breier, G; Brownlee, M; Deutsch, U
(2004).
Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.
Diabetes, 53(4), pp. 1104-10.
Alexandria, Va.: American Diabetes Association
10.2337/diabetes.53.4.1104
2003
Fiedler, U; Krissl, T; Koidl, S; Weiss, C; Koblizek, T; Deutsch, U; Martiny-Baron, G; Marmé, D; Augustin, HG
(2003).
Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats.
Journal of biological chemistry, 3(278), pp. 1721-7.
Bethesda, Md.: American Society for Biochemistry and Molecular Biology
10.1074/jbc.M208550200
2002
Hammes, HP; Lin, J; Renner, O; Shani, M; Lundqvist, A; Betsholtz, C; Brownlee, M; Deutsch, U
(2002).
Pericytes and the pathogenesis of diabetic retinopathy.
Diabetes, 51(10), pp. 3107-12.
Alexandria, Va.: American Diabetes Association
10.2337/diabetes.51.10.3107
Nawroth, R; Poell, G; Ranft, A; Kloep, S; Samulowitz, U; Fachinger, G; Golding, M; Shima, DT; Deutsch, U; Vestweber, D
(2002).
VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts.
EMBO journal, 18(21), pp. 4885-95.
London: Nature Publishing Group
10.1093/emboj/cdf497
Willecke, K; Eiberger, J; Degen, J; Eckardt, D; Romualdi, A; Güldenagel, M; Deutsch, U; Söhl, G
(2002).
Structural and functional diversity of connexin genes in the mouse and human genome.
Biological chemistry, 5(383), pp. 725-737.
Berlin: De Gruyter
10.1515/BC.2002.076
Palmer, A; Zimmer, M; Erdmann, KS; Eulenburg, V; Porthin, A; Heumann, R; Deutsch, U; Klein, R
(2002).
EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase.
Molecular cell, 4(9), pp. 725-37.
Cambridge, Mass.: Cell Press
10.1016/S1097-2765(02)00488-4
2001
Eiberger, J; Degen, J; Romualdi, A; Deutsch, U; Willecke, K; Söhl, G
(2001).
Connexin genes in the mouse and human genome.
Cell communication & adhesion, 8(4-6), pp. 163-5.
Basingstoke, UK: Taylor & Francis
10.3109/15419060109080717
Adams, RH; Diella, F; Hennig, S; Helmbacher, F; Deutsch, U; Klein, R
(2001).
The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration.
Cell, 104(1), pp. 57-69.
Cambridge, Mass.: Cell Press
10.1016/S0092-8674(01)00191-X
Theis, M; de Wit, C; Schlaeger, TM; Eckardt, D; Krüger, O; Döring, B; Risau, W; Deutsch, U; Pohl, U; Willecke, K
(2001).
Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene.
Genesis, 29(1), pp. 1-13.
Hoboken, N.J.: Wiley-Liss
10.1002/1526-968X(200101)29:1<1::AID-GENE1000>3.0.CO;2-0
1999
Fachinger, G; Deutsch, U; Risau, W
(1999).
Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2.
Oncogene, 43(18), pp. 5948-53.
Basingstoke, UK: Nature Publishing Group
10.1038/sj.onc.1202992
Adams, RH; Wilkinson, GA; Weiss, C; Diella, F; Gale, NW; Deutsch, U; Risau, W; Klein, R
(1999).
Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.
Genes & development, 13(3), pp. 295-306.
Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press
10.1101/gad.13.3.295
1998
Reiss, Y; Hoch, G; Deutsch, U; Engelhardt, B
(1998).
T cell interaction with ICAM-1-deficient endothelium in vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells.
European journal of immunology, 28(10), pp. 3086-99.
Weinheim: Wiley-VCH
10.1002/(SICI)1521-4141(199810)28:10<3086::AID-IMMU3086>3.0.CO;2-Z
Knies, UE; Behrensdorf, HA; Mitchell, CA; Deutsch, U; Risau, W; Drexler, HC; Clauss, M
(1998).
Regulation of endothelial monocyte-activating polypeptide II release by apoptosis.
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 95(21), pp. 12322-7.
Washington, D.C.: National Academy of Sciences NAS
10.1073/pnas.95.21.12322
Koblizek, TI; Weiss, C; Yancopoulos, GD; Deutsch, U; Risau, W
(1998).
Angiopoietin-1 induces sprouting angiogenesis in vitro.
Current Biology, 9(8), pp. 529-32.
Cambridge, Mass.: Cell Press
10.1016/S0960-9822(98)70205-2
1997
Mayr, T; Deutsch, U; Kühl, M; Drexler, HC; Lottspeich, F; Deutzmann, R; Wedlich, D; Risau, W
(1997).
Fritz: a secreted frizzled-related protein that inhibits Wnt activity.
Mechanisms of development, 63(1), pp. 109-25.
Shannon: Elsevier
10.1016/S0925-4773(97)00035-X
Schlaeger, TM; Bartunkova, S; Lawitts, JA; Teichmann, G; Risau, W; Deutsch, U; Sato, TN
(1997).
Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 94(7), pp. 3058-63.
Washington, D.C.: National Academy of Sciences NAS
10.1073/pnas.94.7.3058
Koblizek, TI; Runting, AS; Stacker, SA; Wilks, AF; Risau, W; Deutsch, U
(1997).
Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues.
European journal of biochemistry, 244(3), pp. 774-9.
Cambridge: Blackwell Science
10.1111/j.1432-1033.1997.00774.x