Our laboratory addresses the dynamics of autoimmune inflammation in the central nervous system, and more specifically in the main animal model for Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis. By combining cutting-edge brain in vitro barrier models, in vivo imaging techniques and novel transgenic animal models, we can study and model the pathogenic interaction between activated cells of the immune system and parenchymal cells. More in details, we study the complex interaction of activated macrophages with other immune cells, with the central nervous system barriers and with their targets of inflammation within the spinal cord parenchyma, trying to understand how to balance and govern destructive and protective phagocyte polarizations in Multiple Sclerosis. Furthermore, we are exploring the oxidative mechanisms that lead to glial cell stress and demyelination during neuroinflammation. Our final aim is to provide insights in understanding the pathogenesis of tissue injury and clinical degeneration in Multiple Sclerosis.