The Theodor Kocher Institute (TKI) is an institute of the Medical Faculty of the University of Bern. Research at the TKI addresses molecular mechanisms involved in inflammation. A special focus lies on immune cell migration to different organs during immune surveillance and inflammation employing cutting-edge 3D live cell imaging. The specific research focus of the individual TKI research groups are shown in the section Research. Teaching: The institute offers lectures and practical classes in immunology, vascular cell biology, transgenic mouse technologies, cell migration, inflammation and live cell imaging for bachelor, master and graduate students in the Medical, Science and Vetsuisse Faculties. Services: The TKI participates in the Microscopy Imaging Center and provides services in the production of genetically modified mouse models as well as in cryo-preservation and rederivation of mouse strains.
The TKI congratulates Sasha Soldati for the successful defense of his PhD thesis entitled "Targeting T-cell migration to the central nervous system in the context of multiple sclerosis.” and for successfully completing the PhD Program Cell Migration.
Prof. Britta Engelhardt was awarded the Malpighi Medal of the European Society of Microcirculation at the 32nd ESM Meeting in Aarhus, Denmark in April 2023.
The Malpighi Medal is the most prestigious award of the ESM given to an individual of internationally outstanding reputation in any field of microcirculation research. Britta Engelhardt received this award for her contributions on central nervous system microcirculation.
We congratulate Dr. Sarah Guimbal, PostDoc in the group of Britta Engelhardt, for winning the Best Poster Award at iPSZürich 2023 with her poster entitled «New molecular underpinnings of blood-brain barrier dysfunction in multiple sclerosis».
We congratulate Ms. Pelin Kasap, PhD student in the group of Britta Engelhardt, for winning the Best Presentation Award at iPSZürich 2023 with her presentation entitled «An isogenic in vitro model of the human neurovascular unit to explore blood brain barrier dysfunction in neuroinflammation».
Sharing our professional and personal diversity is both a privilege and an enrichment, making us both better scientists and persons.
The war in Ukraine must stop!
As the prevalence of Alzheimer’s disease and Multiple Sclerosis continues to increase, so does the pressure to find suitable treatment options – and with it the need to decipher the physiologic underpinnings of these pathologies. This includes the metabolite clearance and immune surveillance functions of the cerebrospinal fluid (CSF), as well as immune privilege established by the brain barriers, which are disturbed during neuroinflammation. In this Sinergia project funded by the Swiss National Science Foundation, we will investigate how CSF dynamics and brain barriers change with age, neuroinflammation, and neurodegeneration. The project consortium includes the teams of Britta Engelhardt and Steven Proulx (Theodor Kocher Institute, University of Bern), Bert Müller (Biomaterials Science Center, University of Basel), and of Vartan Kurtcuoglu (Institute of Physiology, University of Zurich) as coordinator. For more details please follow the link.
We congratulate Javier Pareja, PhD student in the group of Britta Engelhardt, for winning the Free Communication Prize 2022 at the 5th Swiss Vascular Research Symposium for the presentation entitled: Brain endothelial antigen presentation detains CD8+ T cells at the blood-brain barrier leading to its breakdown
We congratulate Sasha Soldati, PhD student in the group of Britta Engelhardt, for winning the Poster Prize 2022 at the 5th Swiss Vascular Research Symposium for the Poster entitled: Vitamin D regulates - cell migration across the blood-brain barrier
We congratulate Amandine Brenna, PhD student in the group of Britta Engelhardt, for winning a Best Poster Award at the 24th International Symposium on Signal Transduction at the Blood-Brain Barriers” in Bari.
On June 8, 2022 Josephine Mapunda has successfully defended her PhD thesis entitled “Imaging the central nervous system immune privilege: The role of CNS barriers in regulating trafficking of immune cells and immune mediators in the CNS.” The TKI congratulates her to this achievement!
We congratulate Pelin Kasap, PhD student in the group of Britta Engelhardt, to the Best Poster Award at the iPSZürich Symposium 2022.
Britta Engelhardt hielt auf Einladung der Schweizerischen Multiple Sklerose Geschellschaft einen Vortrag in deutscher Sprache über die «Blut-Hirn Schranke bei MS» der hier in gekürzter Form angeschaut werden kann.
The TKI congratulates Federico Saltarin for successful defense of his PhD thesis entitled «Investigations on the extravasation of melanoma cells across the blood brain barrier».
Four medical researchers have been the first in Europe awarded a CSL Research Acceleration Initiative partnership, including an investment of up to 400,000 CHF per program over two years, to fast-track the discovery of innovative biotherapies that address unmet patient needs.
The TKI congratulates Daniela Ivan for successful defense of her PhD thesis entitled «Myeloid cell recruitment to the CNS during neuroinflammation - migration pathways and functional polarizations»
Good-bye to Dr. Hideaki Nishihara from the «Human B-Lab Team» that has grown under his guidance! We will keep up the good work on the human brain barriers and look forward to our future collaborations.
Thank you for everything Ursula and we will miss you..
We are pleased to announce that Sidar Aydin has successfully passed his PhD thesis defence at the TKI. Congratulations!
We are happy to announce that Adrian Madarasz finished his medical doctoral thesis. The Medical Faculty of the University of Bern officially confirmed his title as Dr. med. on September 2, 2020.
Adrian is now performing an MD PhD at our Institute.
No traditional TKI Christmas Party this year. We have missed you all. We wish all previous TKI members and friends and everybody who visits our homepage a wonderful Holiday Season and all the best for the New Year! Take care!
Two TKI scientific collaborators, Kristina Bervé and Daniela Ivan, participated in a Science Filmmaking Marathon which took place in Zurich.
The objective of this marathon was to learn how to use different storytelling and filmmaking tools to communicate scientific results and make science more accessible for the broader audience.
During the three days of the marathon, together with 3 other PhD students of different backgrounds, from ETH and University of Zurich, and helped by a trainer, we made a 4 minutes documentary related to the current COVID-19 pandemic.
Our short film, `NO DENIAL`, highlights a recent discovery made by a team of researchers from the University of Bern and ETH Zurich who studied the mechanisms behind SARS-Covid-19 viral infection and underlines the necessity of a closer collaboration between scientists and media to educate the general public.
The movie will be available online at this website - https://www.sciencefilm.ch/scientists-as-filmmake-2020 starting from tonight until Sunday (5-8th of November) at any time.
If you want to help us promote our movie and the message we want to send 😊, you can link our film to your social media accounts (i.e. Twitter/ Facebook).
With this movie, we are participating in this year´s 3rd Global Science Film Festival, so, keep your fingers crossed for us 😉🤞.
Thanks a lot for reading this long message and we wish you a great end of the week!
All the best,
Daniela and Kristina
The TKI congratulates PD Dr. Ruth Lyck to the nomination as Associate Professor of the University of Bern.
Focusing her research orignially on immune cell migration across the blood-brain barrier, Dr. Lyck has recently shifted her research focus on melanoma cell migration across this tissue barrier in the context of tumor metastasis to the brain. Dr. Lyck has worked part time during her entire career first due to family reasons and lately due to her additional function as the coordinator of the Microscopy Imaging Center (MIC) of the University of Bern. She is thus an excellent female role model for scientists in the future.
His Zoom Seminar talk today entitled "Role of the EphB4-receptor in mediating resistance to antiangiogenic treatment in malignant glioma"
First TKI ZOOM seminar with Professor Roy O. Weller and Dr. Roxane O. Carare, University of Southhampton, UK.
Their presentations "connections between the brain and the immune system" and "clearance of amyloid and interstitial fluid from the aging brain" were truly inspiring!
Prof. Dr. Daniel Legler, head of the Biotechnology Institute Thurgau at the University of Konstanz, has been appointed as associate professor at the Medical Faculty of the University of Bern affiliated with the Theodor Kocher Institute by March 1st, 2020. For several years, Daniel Legler is engaged in the PhD program Cell Migration coordinated by Prof. Dr. Britta Engelhardt. Moreover, Daniel Legler is a member of the expert commission Cell Biology of the Bern Graduate School for Cellular and Biomedical Sciences (GCB) and co-organizer of the annual Cytomeet dedicated to the Swiss scientific community interested in mechanisms of cell migration.
Josephine Mapunda is happy that the virtual mid-term exam is successfully suceeded.
The TKI lab is now up and running virtually
January 31, 2020 | On occasion of the «GCB Symposium 2020», held on January 30, 2020, at the Department of Chemistry and Biochemistry and the Department of Physiology, University of Bern, the «GCB Award for Best PhD Thesis» for the year 2019 was conferred on Mariana Mota Castro Dias, PhD in Neuroscience, for her PhD thesis entitled «The role of the brain-barrier tight junctions in neuroinflammation».
Mariana Dias and Luca Marchetti finished their PhDs at the TKI in 2019
This years ProDoc Cell Migration Retreat took place from August 29 to August 30 at the Hotel Appenberg in the beautiful Emmental near Bern
PhD position at the Theodor Kocher Institute for early stage researchers (ESR) for three years, funded as a Marie Sklodowska-Curie Innovative Training Network (ITN).
For further details of the individual projects in ENTRAIN, please follow the link www.itn-entrain.eu.
Event for researcher and students
And the winner is - Mariana Dias with her friends Daniela Ivan, Josephine Mapunda, Luca Marchetti, Federico Saltarin and Viviane Schallenberg from the Theodor Kocher Institute and David Francisco from Interfaculty Bioinformatics Unit
On January 18, 2019, the Final Network Meeting of BtRAIN took place in Milano.
BtRAIN has educated a unique group of students in brain barriers research and has established a tight network amongst its members that will last beyond this program.
Britta Engelhardt is the coordinator of the Marie Sklodowska Curie Training Network BtRAIN funded by the European Commission Horizon 2020 Programme. At the University of Bern this program is a tight collaboration between the TKI and the Interfaculty Bioinformatics Unit.
2013/07/17 Justbrain Project: Download the JUSTBRAIN Success Story video
Coverstory in September issue of European Journal of Immunology
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