Publications in 2022
PEGylated Gold Nanoparticles Target Age-Associated B Cells In Vivo.
Hočevar S, Puddinu V, Haeni L, Petri-Fink A, Wagner J, Alvarez M, Clift MJD, Bourquin C.
ACS Nano. 2022 Oct 27. doi: 10.1021/acsnano.2c04871. Online ahead of print. PMID: 36301574
Inhibition of IL-1β release from macrophages targeted with necrosulfonamide-loaded porous nanoparticles.
Boersma B, Möller K, Wehl L, Puddinu V, Huard A, Fauteux-Daniel S, Bourquin C, Palmer G, Bein T.
J Control Release. 2022 Oct 13;351:989-1002. doi: 10.1016/j.jconrel.2022.09.063. Online ahead of print. PMID: 36202154
Subcapsular sinus macrophages promote melanoma metastasis to the sentinel lymph nodes via an IL-1alpha-STAT3 axis
Virgilio, T. Bordini, J. Cascione, L. Sartori, G. Latino, I. Molina Romero, D. Leoni, C. Akhmedov, M. Rinaldi, A. Arribas, A. J. Morone, D. Seyed Jafari, S. M. Bersudsky, M. Ottolenghi, A. Kwee, I. Chiaravalli, A. M. Sessa, F. Hunger, R. E. Bruno, A. Mortara, L. Voronov, E. Monticelli, S. Apte, R. N. Bertoni, F. Gonzalez, S. F.
in Cancer Immunol Res (2022) Vol. pp
CANCOL, a Computer-Assisted Annotation Tool to Facilitate Colocalization and Tracking of Immune Cells in Intravital Microscopy
Pizzagalli, D. U. Bordini, J. Morone, D. Pulfer, A. Carrillo-Barbera, P. Thelen, B. Ceni, K. Thelen, M. Krause, R. Gonzalez, S. F.
in J Immunol (2022) Vol. pp
In Vivo Motility Patterns Displayed by Immune Cells Under Inflammatory Conditions
Pizzagalli, D. U. Pulfer, A. Thelen, M. Krause, R. Gonzalez, S. F.
in Front Immunol (2022) Vol.12 pp804159
Behavioural immune landscapes of inflammation
Crainiciuc, G. Palomino-Segura, M. Molina-Moreno, M. Sicilia, J. Aragones, D. G. Li, J. L. Y. Madurga, R. Adrover, J. M. Aroca-Crevillen, A. Martin-Salamanca, S. Del Valle, A. S. Castillo, S. D. Welch, H. C. E. Soehnlein, O. Graupera, M. Sanchez-Cabo, F. Zarbock, A. Smithgall, T. E. Di Pilato, M. Mempel, T. R. Tharaux, P. L. Gonzalez, S. F. Ayuso-Sacido, A. Ng, L. G. Calvo, G. F. Gonzalez-Diaz, I. Diaz-de-Maria, F. Hidalgo, A.
in Nature (2022) Vol. pp
Inflammatory Mediators in Atherosclerotic Vascular Remodeling.
Evans BR, Yerly A, van der Vorst EPC, Baumgartner I, Bernhard SM, Schindewolf M, Döring Y. Front Cardiovasc Med. 2022 May 4
9:868934. doi: 10.3389/fcvm.2022.868934. eCollection 2022. PMID: 35600479 Free PMC article. Review.
Microbial uptake in oral mucosa-draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype.
arreto de Alburquerque J, Altenburger LM, Abe J, von Werdt D, Wissmann S, Martínez Magdaleno J, Francisco D, van Geest G, Ficht X, Iannacone M, Bruggmann R, Mueller C, Stein JV*. Sci Immunol. 2022 Jun 24;
7(72):eabf1861. doi: 10.1126/sciimmunol.abf1861. Epub 2022 Jun 17.
Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation.
Rossatti P, Redpath GMI, Ziegler L, Samson GPB, Clamagirand CD, Legler DF, Rossy J. BMC Biol. 2022 Aug 24
20(1):189. doi: 10.1186/s12915-022-01386-0.
Distinct Fates of Chemokine and Surrogate Molecule Gradients: Consequences for CCR7-Guided Dendritic Cell Migration.
Artinger M, Gerken OJ, Purvanov V, Legler DF. Front Immunol. 2022 Jun 13
13:913366. doi: 10.3389/fimmu.2022.913366. eCollection 2022.
Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake.
Gerken OJ, Artinger M, Legler DF. Cells. 2022 Apr 25
11(9):1444. doi: 10.3390/cells11091444.
Publications in 2021
The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy.
Boersma B, Jiskoot W, Lowe P, Bourquin C.
Cytokine Growth Factor Rev. 2021 Dec;62:1-14. doi: 10.1016/j.cytogfr.2021.09.004. Epub 2021 Sep 24. PMID: 34620560
HMGB1 promotes CXCL12-dependent egress of murine B cells from Peyer's patches in homeostasis.
Spagnuolo L, Puddinu V, Boss N, Spinetti T, Oberson A, Widmer J, Mottas I, Hotz C, Bianchi ME, Uguccioni M, Bourquin C.
Eur J Immunol. 2021 Aug;51(8):1980-1991. doi: 10.1002/eji.202049120. Epub 2021 Jun 16. PMID: 34060652
Mesoporous Silica Nanoparticles as pH-Responsive Carrier for the Immune-Activating Drug Resiquimod Enhance the Local Immune Response in Mice.
Wagner J, Gößl D, Ustyanovska N, Xiong M, Hauser D, Zhuzhgova O, Hočevar S, Taskoparan B, Poller L, Datz S, Engelke H, Daali Y, Bein T, Bourquin C.
ACS Nano. 2021 Mar 23;15(3):4450-4466. doi: 10.1021/acsnano.0c08384. Epub 2021 Mar 1. PMID: 33648336
Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection
Di Pilato, M. Palomino-Segura, M. Mejias-Perez, E. Gomez, C. E. Rubio-Ponce, A. D'Antuono, R. Pizzagalli, D. U. Perez, P. Kfuri-Rubens, R. Benguria, A. Dopazo, A. Ballesteros, I. Sorzano, C. O. S. Hidalgo, A. Esteban, M. Gonzalez, S. F.
in NPJ Vaccines (2021) Vol.6 pp52
Carboxymethyl-beta-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen delivery
Cordeiro, A. S. Farsakoglu, Y. Crecente-Campo, J. de la Fuente, M. Gonzalez, S. F. Alonso, M. J.
in Drug Deliv Transl Res (2021) Vol. pp
Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases.
Thakur M, Evans B, Schindewolf M, Baumgartner I, Döring Y. Cells. 2021 Jul 4
10(7):1689. doi: 10.3390/cells10071689. PMID: 34359859 Free PMC article. Review.
Inflammatory Chemokines in Atherosclerosis.
Gencer S, Evans BR, van der Vorst EPC, Döring Y, Weber C. Cells. 2021 Jan 25
10(2):226. doi: 10.3390/cells10020226. PMID: 33503867 Free PMC article. Review.
The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis.
Thelen F, Wissmann S, Ruef N, Stein JV*. Front Immunol. 2021 Sep 9
12:716405. doi: 10.3389/fimmu.2021.716405. eCollection 2021.
Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse.
Leithner A, Altenburger LM, Hauschild R, Assen FP, Rottner K, Stradal TEB, Diz-Muñoz A, Stein JV, Sixt M. J Cell Biol. 2021 Apr 5
220(4):e202006081. doi: 10.1083/jcb.202006081.
Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells.
Alcaraz-Serna A, Bustos-Morán E, Fernández-Delgado I, Calzada-Fraile D, Torralba D, Marina-Zárate E, Lorenzo-Vivas E, Vázquez E, de Alburquerque JB, Ruef N, Gómez MJ, Sánchez-Cabo F, Dopazo A, Stein JV, Ramiro A, Sánchez-Madrid F. Sci Adv. 2021 Feb 3
7(6):eabb9965. doi: 10.1126/sciadv.abb9965. Print 2021 Feb. PMID: 33536205
CAL-1 as Cellular Model System to Study CCR7-Guided Human Dendritic Cell Migration.
Uetz-von Allmen E, Samson GPB, Purvanov V, Maeda T, Legler DF. Front Immunol. 2021 Sep 16
12:702453. doi: 10.3389/fimmu.2021.702453. eCollection 2021.
The dimeric form of CXCL12 binds to atypical chemokine receptor 1.
Gutjahr JC, Crawford KS, Jensen DR, Naik P, Peterson FC, Samson GPB, Legler DF, Duchene J, Veldkamp CT, Rot A, Volkman BF. Sci Signal. 2021 Aug 17
14(696):eabc9012. doi: 10.1126/scisignal.abc9012.
A Versatile Toolkit for Semi-Automated Production of Fluorescent Chemokines to Study CCR7 Expression and Functions.
Artinger M, Matti C, Gerken OJ, Veldkamp CT, Legler DF. Int J Mol Sci. 2021 Apr 16
22(8):4158. doi: 10.3390/ijms22084158.
Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids.
Phan TS, Schink L, Mann J, Merk VM, Zwicky P, Mundt S, Simon D, Kulms D, Abraham S, Legler DF, Noti M, Brunner T. Sci Adv. 2021 Jan 29
7(5):eabe0337. doi: 10.1126/sciadv.abe0337. Print 2021 Jan.
Publications in 2020
Silver-Containing Titanium Dioxide Nanocapsules for Combating Multidrug-Resistant Bacteria.
Hérault N, Wagner J, Abram SL, Widmer J, Horvath L, Vanhecke D, Bourquin C, Fromm KM. Int J Nanomedicine. 2020 Feb 25
15:1267-1281. doi: 10.2147/IJN.S231949. eCollection 2020. PMID: 32161457
Spatio-temporal profile of innate inflammatory cells and mediators during influenza virus infection
Latino, I. Gonzalez F., S.
in Curr Opin Physiol (2020) Vol.19 pp175-186
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells
Eisinger, S. Sarhan, D. Boura, V. F. Ibarlucea-Benitez, I. Tyystjarvi, S. Oliynyk, G. Arsenian-Henriksson, M. Lane, D. Wikstrom, S. L. Kiessling, R. Virgilio, T. Gonzalez, S. F. Kaczynska, D. Kanatani, S. Daskalaki, E. Wheelock, C. E. Sedimbi, S. Chambers, B. J. Ravetch, J. V. Karlsson, M. C. I.
in Proc Natl Acad Sci U S A (2020) Vol.117 pp32005-32016
Dynamic spherical harmonics approach for shape classification of migrating cells
Medyukhina A, Blickensdorf M, Cseresnyés Z, Ruef N, Stein JV, Figge MT. Sci Rep. 2020 Apr 8
10(1):6072. doi: 10.1038/s41598-020-62997-7.
Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance.
Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser KA, Jafari SMS, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV*. Sci Immunol. 2020 Apr 3
5(46). pii: eaaz4371. doi: 10.1126/sciimmunol.aaz4371.
CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems.
Kouzeli A, Collins PJ, Metzemaekers M, Meyrath M, Szpakowska M, Artinger M, Struyf S, Proost P, Chevigne A, Legler DF, Eberl M, Moser B. Front Immunol. 2020 Oct 5
11:561404. doi: 10.3389/fimmu.2020.561404. eCollection 2020.
β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4.
D'Agostino G, Artinger M, Locati M, Perez L, Legler DF, Bianchi ME, Rüegg C, Thelen M, Marchese A, Rocchi MBL, Cecchinato V, Uguccioni M. Front Immunol. 2020 Sep 18
11:550824. doi: 10.3389/fimmu.2020.550824. eCollection 2020.
CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity.
Gutjahr JC, Bayer E, Yu X, Laufer JM, Höpner JP, Tesanovic S, Härzschel A, Auer G, Rieß T, Salmhofer A, Szenes E, Haslauer T, Durand-Onayli V, Ramspacher A, Pennisi SP, Artinger M, Zaborsky N, Chigaev A, Aberger F, Neureiter D, Pleyer L, Legler DF, Orian-Rousseau V, Greil R, Hartmann TN. Haematologica. 2021 Aug 1
106(8):2102-2113. doi: 10.3324/haematol.2019.231944.
CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
Matti C, D'Uonnolo G, Artinger M, Melgrati S, Salnikov A, Thelen S, Purvanov V, Strobel TD, Spannagel L, Thelen M, Legler DF. J Leukoc Biol. 2020 Jun
107(6):1137-1154. doi: 10.1002/JLB.2MA0420-295RRR.
Membrane Compartmentalization and Scaffold Proteins in Leukocyte Migration.
Samson GPB, Legler DF. Front Cell Dev Biol. 2020 Apr 28
8:285. doi: 10.3389/fcell.2020.00285. eCollection 2020.
ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins.
Matti C, Salnikov A, Artinger M, D'Agostino G, Kindinger I, Uguccioni M, Thelen M, Legler DF. Front Immunol. 2020 Apr 22
11:720. doi: 10.3389/fimmu.2020.00720. eCollection 2020.
Publications in 2019
Early production of IL-17A by gammadelta T cells in the trachea promotes viral clearance during influenza infection in mice
M. Palomino-Segura, I. Latino, Y. Farsakoglu, S. F. Gonzalez
in Eur J Immunol (2019) vol. 50 pp97-109
Characterization of the Dynamic Behavior of Neutrophils Following Influenza Vaccination
D. U. Pizzagalli, I. Latino, A. Pulfer, M. Palomino-Segura, T. Virgilio, Y. Farsakoglu, R. Krause, S. F. Gonzalez
in Frontiers in Immunology (2019) vol. 10
Design of polymeric nanocapsules to improve their lympho-targeting capacity
J. Crecente-Campo, T. Virgilio, D. Morone, C. Calvino-Sampedro, I. Fernandez-Marino, A. Olivera, R. Varela-Calvino, S. F. Gonzalez, M. J. Alonso
in Nanomedicine (Lond) (2019) vol. 14 pp3013-3033
Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1
M. Palomino-Segura, L. Perez, Y. Farsakoglu, T. Virgilio, I. Latino, R. D'Antuono, N. Chatziandreou, D. U. Pizzagalli, G. Wang, A. Garcia-Sastre, F. Sallusto, M. C. Carroll, O. Neyrolles, S. F. Gonzalez
in Nat Microbiol (2019) vol. 4 pp1930-1940
Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner
Y. Farsakoglu, M. Palomino-Segura, I. Latino, S. Zanaga, N. Chatziandreou, D. U. Pizzagalli, A. Rinaldi, M. Bolis, F. Sallusto, J. V. Stein, S. F. Gonzalez
in Cell Rep (2019) vol. 26 pp2307-2315 e5
Two-Photon Intravital Imaging of Leukocytes in the Trachea During Pneumococcal Infection
M. Palomino-Segura, S. F. Gonzalez
in Methods Mol Biol (2019) vol. 1968 pp183-194
In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell-Mediated Host Surveillance.
Ficht X, Ruef N, Stolp B, Samson GPB, Moalli F, Page N, Merkler D, Nichols BJ, Diz-Muñoz A, Legler DF, Niggli V, Stein JV.
J Immunol. 2019 Nov 1;203(9):2377-2387.
Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7.
Jakobs BD, Spannagel L, Purvanov V, Uetz-von Allmen E, Matti C, Legler DF.
Int J Mol Sci. 2019 May 27;20(10).
CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70.
Laufer JM, Kindinger I, Artinger M, Pauli A, Legler DF.
Front Immunol. 2019 Jan 14;9:3115.
Claudin-12 is not required for blood-brain barrier tight junction function.
Castro Dias, Mariana; Caroline Coisne, Pascale Baden, Gaby Enzmann, Lillian Garrett, Lore Becker, Sabine M. Hölter, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Urban Deutsch, Britta Engelhardt.
Fluid Barriers CNS 2019 – Sep 12;16(1):30. doi: 10.1186/s12987-019-0150-9.
Claudin-3-deficient C57BL/6J mice display intact brain barriers
Castro Dias, Mariana; Caroline Coisne, Ivana Lazarevic, Pascale Baden, Masaki Hata, Noriko Iwamoto, David Miguel Ferreira Francisco, Michael Vanlandewijck, Liqun He, Felix A. Baier, Deborah Stroka, Rémy Bruggmann, Ruth Lyck, Gaby Enzmann, Urban Deutsch, Christer Betsholtz, Mikio Furuse, Shoichiro Tsukita and Britta Engelhardt.
Sci Reports 2019 Jan 18;9(1):203. doi: 10.1038/s41598-018-36731-3.
Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers.
Castro Dias, Mariana; Josephine A. Mapunda; Mykhailo Vladymyrov; Britta Engelhardt.
Int J Mol Sci 2019. 20(21), 5372; doi.org/10.3390/ijms20215372
Silver-containing titanium oxide nanocapsules for combating multidrug-resistant bacteria.
Hérault N*, Wagner J*, Abram SL, Widmer J, Horvath L, Vanhecke D, Bourquin C*,. Fromm M*. (*shared first and senior authorship).
International Journal of Nanomedicine, 2019, in press (JIF 4.5)
Hočevar S, Milošević A, Rodriguez-Lorenzo L, Ackermann-Hirschi L, Mottas I, Petri-Fink A, Rothen-Rutishauser B, Bourquin C*, Clift MJD* (*shared senior authorship)
Polymer-coated gold nanospheres do not impair the innate immune function of human B lymphocytes in vitro
ACS Nano, 2019, 13:6790-6800. (JIF 13.9)
Thauvin C, Widmer J, Mottas I, Hocevar S, Allémann E, Bourquin C*, Delie F* (*shared senior authorship)
Development of resiquimod-loaded modified PLA-based nanoparticles for cancer immunotherapy: A kinetic study
Eur J Pharm Biopharm, 2019, 139:253-261. (JIF 4.6)
Mottas I*; Bekdemir A*; Cereghetti A; Spagnuolo L; Yang YS; Müller M; Irvine D; Stellacci F*; Bourquin C* (*shared first and senior authorship)
Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation
Biomaterials, 2019, 190-191:111-120. (JIF 8.8)
Fico F, Bousquenaud M, Rüegg C, Santamaria-Martínez A.
Breast Cancer Stem Cells with Tumor- versus Metastasis-Initiating Capacities Are Modulated by TGFBR1 Inhibition.
Stem Cell Reports. 2019 Jul 9;13(1):1-9. Doi: 10.1016/j.stemcr.2019.05.026.
K. Ghimire, J. Zaric, B. Alday Parejo, J. Seebac, M. Bousquenaud, G. Bieler, J. Stalin, H-J. Schnittler and C. Ruegg.
Endothelial cell MAGI1 promotes PKA-dependent eNOS activation in response to fluid shear stress. (2019)
Cells Apr 27;8(5). pii: E388. doi: 10.3390/cells8050388.
B. Alday Parejo, R. Stupp and C. Rüegg
Are integrins still practicable targets for anti-cancer therapy? (2019).
Cancers (Basel). 2019 Jul 12;11(7). pii: E978. doi: 10.3390/cancers11070978
C. Rüegg, C. Reis, S. Rafiee, L. Rodriguez-Lorenzo, J. List, B. Rothen-Rutishauser, M. Mayer, and A. Petri-Fink.
A bioinspired amplification cascade for the detection of rare cancer cells. (2019) Chimia (Aarau). 2019 Feb
27;73(1):63-68. doi: 10.2533/chimia.2019.63.
More scientific Publications
within the framework of the PhD Program Cell Migration can be found under this link http://p3.snf.ch/project-137087
