General lecture Information
General learning goal of the lecture DYNCELCON
The lecture series "Dynamics of Cellular Contacts: Cell Adhesion and Cell Motility" is held by lecturers whose research activities are in the field of cell adhesion and cell migration. The lecture series explains in depth the cellular and molecular mechanisms of cell adhesion and cell migration and deepens this knowledge with specific examples from current research from the lecturers' areas of expertise. The students thus get a comprehensive and deep insight into the molecular mechanisms of cell migration and how these can be researched.
Course Description
- Cell-cell junctions and cell migration at a glance – an introduction
- Cytoskeleton - a dynamic structure: structural proteins and small GTPases
- Cell adhesion to extracellular matrix: Extracellular matrix (collagens, laminins...) their receptors, i.e. integrins
- Adherens junctions and desmosomes: How cells are glued together
- Tight junctions and gap junctions: fences, gates and channels connecting adjacent cells
- Cell Motility I: Polarization, protrusions, adhesive interactions and retraction translate into cell migration
- Cell Motility II: ezrin/radixin/moesin (ERM) proteins
- Cell Migration I: Chemotaxis, gradients, neural crest cell migration
- Cell Migration II: Cell-cell adhesion (leukocyte/endothelial interaction)
- Dynamics of cellular contacts and extracellular matrix
- Vascular morphogenesis and neovessel stabilization
- Guidance molecules direct cell movement (ephrins, semaphorins etc.)
- The multi-step process of cancer metastasis
- In vivo and in vitro techniques to study cell migration
Target Audience
- Master students of Biomedical Sciences and Molecular Life Sciences
- PhD students in the GCB program
Prerequisites
Prerequisites for this lecture are:
Schedule
Fall semester, 2 hour lecture a week, 3 ETCS
KSL/Ilias
No. 2222
This lecture ist coordinated by the Theodor Kocher Institute
